{"id":362,"date":"2026-01-10T13:38:00","date_gmt":"2026-01-10T04:38:00","guid":{"rendered":"https:\/\/neuro-machida.jp\/blog\/?p=362"},"modified":"2026-01-10T18:49:57","modified_gmt":"2026-01-10T09:49:57","slug":"post-362","status":"publish","type":"post","link":"https:\/\/neuro-machida.jp\/blog\/post-362\/","title":{"rendered":"\u65b0\u3057\u3044\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6cbb\u7642\u85ac\u304c\u4f7f\u7528\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\uff1a\u30d9\u30e0\u307a\u30c9\u9178\uff08\u30cd\u30af\u30bb\u30c8\u30fc\u30eb\uff09\u306f\u30b9\u30bf\u30c1\u30f3\u306e\u52b9\u679c\u304c\u5341\u5206\u3067\u306a\u3044\u65b9\u3084\u526f\u4f5c\u7528\u306e\u3042\u308b\u65b9\u306b\u6709\u52b9\u3067\u3059"},"content":{"rendered":"\n

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\u30d9\u30e0\u30da\u30c9\u9178\uff08\u30cd\u30af\u30bb\u30c8\u30fc\u30eb\u3000\u5927\u585a\u88fd\u85ac\uff09\u306f\u30b9\u30bf\u30c1\u30f3\u304c\u50cd\u304f\u5834\u6240\u3088\u308a\u3082\u4e0a\u6d41\u306eATP\u30af\u30a8\u30f3\u9178\u30ea\u30a2\u30fc\u30bc (ACL) \u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092 15\u301c25%\u4f4e\u4e0b\u3055\u305b\u307e\u3059\u3002\u3053\u306e\u85ac\u5264\u306e\u7279\u5fb4\u306f\u3001\u7b4b\u8089\u306b\u306f\u6d3b\u6027\u5316\u3055\u305b\u308b\u9175\u7d20\u304c\u306a\u3044\u305f\u3081\u306b\u3001\u7b4b\u8089\u306b\u306f\u4f5c\u7528\u3057\u306a\u3044\u70b9\u306b\u3042\u308a\u307e\u3059\u3002\u30b9\u30bf\u30c1\u30f3\u306b\u898b\u3089\u308c\u308b\u7b4b\u8089\u306e\u526f\u4f5c\u7528\u306f\u8d77\u3053\u308a\u307e\u305b\u3093\u3002\u4e00\u65b9\u3001\u30d9\u30e0\u30da\u30c9\u9178\u306e\u4ee3\u8b1d\u7523\u7269\u306f\u3001\u814e\u81d3\u3067\u5c3f\u9178\u3092\u6392\u6cc4\u3059\u308b\u305f\u3081\u306b\u50cd\u304f\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u3068\u540c\u3058\u7d4c\u8def\u3067\u6392\u6cc4\u3055\u308c\u308b\u305f\u3081\u306b\u7af6\u5408\u3057\u3001\u5c3f\u9178\u306e\u6392\u6cc4\u3092\u963b\u5bb3\u3057\u307e\u3059\u3002\u5c3f\u9178\u5024\u306e\u9ad8\u3044\u4eba\u306b\u306f\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002\u30d9\u30e0\u307a\u30c8\u9178\uff08\u30cd\u30af\u30bb\u30c8\u30fc\u30eb\uff09\u306f\u30b9\u30bf\u30c1\u30f3\u306e\u52b9\u679c\u304c\u5341\u5206\u3067\u306a\u3044\u65b9\u3084\u526f\u4f5c\u7528\u306e\u3042\u308b\u65b9\u306b\u6709\u52b9\u3067\u3059\u3002<\/p>\n\n\n\n

2230\u540d\u304c\u53c2\u52a0\u3057\u305f\u7121\u4f5c\u70ba\u5316\u5bfe\u7167\u8a66\u9a13\u306e\u7d50\u679c\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002\u6700\u5927\u8010\u7528\u91cf\u306e\u30b9\u30bf\u30c1\u30f3\u306b\u3088\u308b\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u60a3\u8005\u3055\u3093\u3067\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c70mg\u4ee5\u4e0a\u3042\u308b\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u3001\u30d8\u30c6\u30ed\u63a5\u5408\u4f53\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u3092\u6709\u3059\u308b\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u60a3\u8005\u306f2\u5bfe1\u306e\u5272\u5408\u3067\u30d9\u30e0\u30da\u30c9\u9178\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u3092\u53d7\u3051\u308b\u3088\u3046\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u307e\u3057\u305f\u3002\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u5b89\u5168\u6027\u3067\u3042\u308a\u3001\u4e3b\u305f\u308b\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\uff08\u4e3b\u8981\u6709\u52b9\u6027\u8a55\u4fa1\u9805\u76ee\uff09\u306f52\u9031\u9593\u4e2d\u306e12\u9031\u76ee\u306b\u304a\u3051\u308bLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u767e\u5206\u7387\u5909\u5316\u3068\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u30011488\u540d\u304c\u30d9\u30e0\u30da\u30c9\u9178\u7fa4\u3001742\u540d\u304c\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u307e\u3057\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306e\u5e73\u5747\uff08\u00b1\u6a19\u6e96\u504f\u5dee\uff09LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306f103.2\u00b129.4 mg\/dL\u3067\u3057\u305f\u3002\u4ecb\u5165\u671f\u9593\u4e2d\u306e\u6709\u5bb3\u4e8b\u8c61\u767a\u751f\u7387\u306f\u3001\u30d9\u30e0\u30da\u30c9\u9178\u7fa4\u30671487\u4f8b\u4e2d1167\u4f8b\uff0878.5%\uff09\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067742\u4f8b\u4e2d584\u4f8b\uff0878.7%\uff09\u3068\u3001\u4e21\u7fa4\u3067\u5927\u304d\u306a\u5dee\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u30ec\u30b8\u30e1\u30f3\u4e2d\u6b62\u306b\u81f3\u3063\u305f\u6709\u5bb3\u4e8b\u8c61\u306e\u767a\u751f\u7387\u306f\u30d9\u30e0\u30da\u30c9\u9178\u7fa4\u3067\u9ad8\u304f\uff08162\u4f8bvs 53\u4f8b\uff09\u3001\u75db\u98a8\u306e\u767a\u751f\u7387\u3082\u30d9\u30e0\u30da\u30c9\u9178\u7fa4\u3067\u9ad8\u3044\u7d50\u679c\u3068\u306a\u308a\u307e\u3057\u305f\uff0818\u4f8bvs 2\u4f8b\uff09\u300212\u9031\u76ee\u306b\u304a\u3044\u3066\u3001\u30d9\u30e0\u30da\u30c9\u9178\u306f\u5e73\u5747LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u309219.2 mg\/dL\u4f4e\u4e0b\u3055\u305b\u3001\u3053\u308c\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u221216.5%\u306e\u5909\u5316\u306b\u76f8\u5f53\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u30d9\u30e0\u30da\u30c9\u9178\u306f\u4e00\u65e51\u56de180mg1\u9320\u3092\u670d\u7528\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\u4ee5\u4e0b\u306b\u901a\u5e38\u7528\u3044\u3089\u308c\u308b\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6cbb\u7642\u85ac\u3092\u793a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\u5206\u985e<\/td>LDL<\/td>\u4e2d\u6027\u8102\u80aa<\/td>\u526f\u4f5c\u7528<\/td>\u4e00\u822c\u540d<\/td><\/tr>
\u30b9\u30bf\u30c1\u30f3<\/td>\u2193\u2193\u2193<\/strong><\/td>\u2193<\/strong><\/td>\u6a2a\u7d0b\u7b4b\u878d\u89e3\u75c7\u30fb\u7b4b\u8089\u75db\u30fb\u809d\u969c\u5bb3<\/td>\u30d7\u30e9\u30d0\u30b9\u30bf\u30c1\u30f3 \u30b7\u30f3\u30d0\u30b9\u30bf\u30c1\u30f3 \u30d5\u30eb\u30d0\u30b9\u30bf\u30c1\u30f3 \u30a2\u30c8\u30eb\u30d0\u30b9\u30bf\u30c1\u30f3 \u30d3\u30bf\u30d0\u30b9\u30bf\u30c1\u30f3 \u30ed\u30b9\u30d0\u30b9\u30bf\u30c1\u30f3<\/td><\/tr>
\u5c0f\u8178\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u963b\u5bb3\u85ac<\/td>\u2193\u2193<\/strong><\/td>\u2193<\/strong><\/td>\u6d88\u5316\u5668\u75c7\u72b6\u30fb\u809d\u969c\u5bb3\u30fb\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u3068\u4f75\u7528\u6ce8\u610f<\/td>\u30a8\u30bc\u30c1\u30df\u30d6<\/td><\/tr>
\u30cb\u30b3\u30c1\u30f3\u9178\u8a98\u5c0e\u4f53<\/td>\u2193<\/strong><\/td>\u2193\u2193<\/strong><\/td>\u9854\u9762\u7d05\u6f6e\u30fb\u982d\u75db\u30fb\u809d\u969c\u5bb3<\/td>\u30cb\u30b3\u30c1\u30f3\u9178\u30c8\u30b3\u30d5\u30a7\u30ed\u30fc\u30eb<\/td><\/tr>
ATP\u30af\u30a8\u30f3\u9178\u30ea\u30a2\u30fc\u30bc\u963b\u5bb3\u5264<\/td>\u2193\u2193<\/strong><\/td>\u2015<\/strong><\/td>\u75db\u98a8<\/td>\u30d9\u30e0\u30da\u30c9\u9178<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

\u52d5\u8108\u786c\u5316\u6027\u75be\u60a3\u4e88\u9632\u306e\u305f\u3081\u306e\u8102\u8cea\u7570\u5e38\u75c7\u8a3a\u7642\u30ac\u30a4\u30c92018\u5e74\u7248\u3000\u65e5\u672c\u52d5\u8108\u786c\u5316\u5b66\u4f1a<\/p>\n\n\n\n

Ray KK, Bays HE, Catapano AL, Lalwani ND, Bloedon LT, Sterling LR, Robinson PL, Ballantyne CM; CLEAR Harmony Trial. Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol. N Engl J Med. 2019 Mar 14;380(11):1022-1032. doi: 10.1056\/NEJMoa1803917. PMID: 30865796.<\/p>\n\n\n\n

AI\u5229\u7528<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

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