{"id":357,"date":"2025-12-01T09:26:12","date_gmt":"2025-12-01T00:26:12","guid":{"rendered":"https:\/\/neuro-machida.jp\/blog\/?p=357"},"modified":"2025-12-01T10:23:48","modified_gmt":"2025-12-01T01:23:48","slug":"post-357","status":"publish","type":"post","link":"https:\/\/neuro-machida.jp\/blog\/post-357\/","title":{"rendered":"\u65b0\u3057\u3044\u7761\u7720\u85ac\uff08\u30aa\u30ec\u30ad\u30b7\u30f3\u53d7\u5bb9\u4f53\u62ee\u6297\u85acDORA\uff09\u304c\u4f7f\u7528\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\uff1a\u30dc\u30eb\u30ce\u30ec\u30ad\u30b5\u30f3\u30c8\uff08\u30dc\u30eb\u30ba\u30a3\uff09"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u30dc\u30eb\u30ce\u30ec\u30ad\u30b5\u30f3\u30c8\u306f\u3001\u30aa\u30ad\u30b5\u30a2\u30b8\u30ca\u30f3\u74b0\u3092\u5c0e\u5165\u3059\u308b\u3053\u3068\u3067\u8102\u6eb6\u6027\u3092\u4f4e\u6e1b\u3057\u3001\u6d88\u5931\u534a\u6e1b\u671f\uff08T1\/2\uff09\u3092\u77ed\u304f\u3057\u305f\u85ac\u5264\u3067\u3059\u3002\u5065\u5eb7\u6210\u4eba\u306b\u304a\u3051\u308b\u6700\u9ad8\u8840\u4e2d\u6fc3\u5ea6\u5230\u9054\u6642\u9593\uff08Tmax\uff09\u306f0.5\u6642\u9593\u3001T1\/2\u306f2.13\u6642\u9593\u3068\u901f\u3084\u304b\u306a\u5438\u53ce\u3068\u77ed\u3044\u534a\u6e1b\u671f\u304c\u7279\u5fb4\u3067\u3059\uff08\u4e0b\u8a18\u306e\u8868\u53c2\u7167\uff09\u3002\u3053\u308c\u307e\u3067\u4ed6\u306e\u30aa\u30ec\u30ad\u30b7\u30f3\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\uff08DORA\uff09\u3067\u306f\u7fcc\u671d\u306e\u6301\u3061\u8d8a\u3057\u52b9\u679c\u3092\u611f\u3058\u308b\u65b9\u306b\u306f\u3088\u3044\u9069\u5fdc\u306b\u306a\u308a\u307e\u3059\u3002\u4e00\u65b9\u3001\u65e9\u304f\u76ee\u304c\u899a\u3081\u3066\u3057\u307e\u3046\u306a\u3069\u5341\u5206\u306a\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u306a\u3044\u65b9\u304c\u3044\u308b\u304b\u3082\u77e5\u308c\u307e\u305b\u3093\u3002\u7761\u7720\u85ac\u306f\u500b\u4eba\u5dee\u304c\u5927\u304d\u306a\u85ac\u3067\u3059\u306e\u3067\u3001\u81ea\u5206\u306b\u5408\u3063\u305f\u85ac\u3092\u898b\u3064\u3051\u308b\u306e\u304c\u3088\u3044\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30aa\u30ec\u30ad\u30b7\u30f3\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac (DORA)\u306f\u3001\u30dc\u30eb\u30ce\u30ec\u30ad\u30b5\u30f3\u30c8\uff08\u30dc\u30eb\u30ba\u30a3\uff09\u3092\u542b\u3081\u3066\u73fe\u57284\u7a2e\u985e\u3042\u308a\u307e\u3059\u304c\u3001\u3059\u3079\u3066\u4e3b\u8981\u306a\u4ee3\u8b1d\u9175\u7d20\u306fCYP3A4\u306b\u4f9d\u5b58\u3057\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u533b\u85ac\u54c1\u306e\u534a\u5206\u4ee5\u4e0a\u306f\u3053\u306eCYP3A4\u306b\u3088\u3063\u3066\u4ee3\u8b1d\u3055\u308c\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002CYP3A4\u306f\u809d\u81d3\u306b\u6700\u3082\u591a\u304f\u542b\u307e\u308c\u307e\u3059\u3002\u5c0f\u8178\u306b\u3082\u542b\u307e\u308c\u3001\u7d4c\u53e3\u3067\u6442\u53d6\u3057\u305f\u85ac\u5264\u304c\u4f53\u5185\u306b\u5438\u53ce\u3055\u308c\u308b\u524d\u306b\u4ee3\u8b1d\u3092\u53d7\u3051\u307e\u3059\uff08\u5f53\u30d6\u30ed\u30b0\u3001\u30b0\u30ec\u30fc\u30d7\u30d5\u30eb\u30fc\u30c4\u3068\u85ac\u306e\u98f2\u307f\u5408\u308f\u305b\u3092\u53c2\u7167\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7761\u7720\u85ac\u306e\u5834\u5408\u306f\u7279\u306b\u3001CYP3A4\u3092\u5f37\u304f\u963b\u5bb3\u3059\u308b\u85ac\u5264\u3068\u4e00\u7dd2\u306b\u670d\u7528\u3057\u305f\u5834\u5408\u3001\u5927\u304d\u306a\u554f\u984c\u3092\u304d\u305f\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30aa\u30ec\u30ad\u30b7\u30f3\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac(DORA)\u306e\u8840\u4e2d\u6fc3\u5ea6\u304c\u4e0a\u6607\u3057\u3001\u904e\u5ea6\u306e\u93ae\u9759\u3001\u50be\u7720\u3001\u3075\u3089\u3064\u304d\u306a\u3069\u306e\u526f\u4f5c\u7528\u304c\u5897\u5f37\u3055\u308c\u308b\u30ea\u30b9\u30af\u304c\u3042\u308b\u305f\u3081\u3067\u3059\u3002\u6297\u771f\u83cc\u85ac\uff08\u8db3\u767d\u766c\u306a\u3069\uff09\u306e\u30a4\u30c8\u30e9\u30b3\u30ca\u30be\u30fc\u30eb\u306a\u3069\u3001\u6297\u751f\u7269\u8cea\u306e\u30af\u30e9\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u3001\u65b0\u578b\u30b3\u30ed\u30ca\u30a6\u30a4\u30eb\u30b9\u6cbb\u7642\u85ac\u3067\u3042\u308b\u30a8\u30f3\u30b7\u30c8\u30ec\u30eb\u30d3\u30eb\uff08\u30be\u30b3\u30fc\u30d0\uff09\u3068\u306e\u4f75\u7528\u306f\u7981\u5fcc\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5404\u7a2e\u30aa\u30ec\u30ad\u30b7\u30f3\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\u306e\u7279\u5fb4<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>\u88fd\u5264\u540d<\/td><td>\u5546\u54c1\u540d<\/td><td>\u5264\u578b(mg)<\/td><td>Tmax(\u6642\u9593)<\/td><td>T1\/2\uff08\u6642\u9593\uff09<\/td><\/tr><tr><td>\u30ec\u30f3\u30dc\u30ad\u30b5\u30f3\u30c8<\/td><td>\u30c7\u30a8\u30d3\u30b4<\/td><td>8<\/td><td>1.5<\/td><td>50<\/td><\/tr><tr><td>\u30b9\u30dd\u30ec\u30ad\u30b5\u30f3\u30c8<\/td><td>\u30d9\u30eb\u30bd\u30e0\u30e9<\/td><td>10 15 20<\/td><td>1.5<\/td><td>10<\/td><\/tr><tr><td>\u30c0\u30ea\u30c9\u30ec\u30ad\u30b5\u30f3\u30c8<\/td><td>\u30af\u30fc\u30d3\u30d3\u30c3\u30af<\/td><td>25 50<\/td><td>0.75~1.42<\/td><td>6.16~6.92<\/td><\/tr><tr><td>\u30dc\u30eb\u30ce\u30ec\u30ad\u30b5\u30f3\u30c8<\/td><td>\u30dc\u30eb\u30ba\u30a3<\/td><td>2.5 5 10<\/td><td>0.5<\/td><td>2.13<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Tmax\u3000\u85ac\u3092\u98f2\u3093\u3067\u304b\u3089\u8840\u4e2d\u6fc3\u5ea6\u304c\u6700\u3082\u9ad8\u304f\u306a\u308b\u307e\u3067\u306e\u6642\u9593<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">T1\/2\u3000\u8840\u4e2d\u6fc3\u5ea6\u304c\u6700\u3082\u9ad8\u304f\u306a\u3063\u3066\u304b\u3089\u534a\u6e1b\u3059\u308b\u306e\u306b\u304b\u304b\u308b\u6642\u9593<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"600\" src=\"https:\/\/neuro-machida.jp\/blog\/wp-content\/uploads\/2025\/12\/5028c62525538190675a3415340d3391-800x600.jpg\" alt=\"\" class=\"wp-image-358\" srcset=\"https:\/\/neuro-machida.jp\/blog\/wp-content\/uploads\/2025\/12\/5028c62525538190675a3415340d3391-800x600.jpg 800w, https:\/\/neuro-machida.jp\/blog\/wp-content\/uploads\/2025\/12\/5028c62525538190675a3415340d3391-400x300.jpg 400w, https:\/\/neuro-machida.jp\/blog\/wp-content\/uploads\/2025\/12\/5028c62525538190675a3415340d3391.jpg 2000w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u3084\u307e\u307b\u305f\u308b\u3076\u304f\u308d\uff08\u5317\u5cb3\u3000\u8349\u3059\u3079\u308a\u30008\u6708\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30dc\u30eb\u30ce\u30ec\u30ad\u30b5\u30f3\u30c8\u306f\u3001\u30aa\u30ad\u30b5\u30a2\u30b8\u30ca\u30f3\u74b0\u3092\u5c0e\u5165\u3059\u308b\u3053\u3068\u3067\u8102\u6eb6\u6027\u3092\u4f4e\u6e1b\u3057\u3001\u6d88\u5931\u534a\u6e1b\u671f\uff08T1\/2\uff09\u3092\u77ed\u304f\u3057\u305f\u85ac\u5264\u3067\u3059\u3002\u5065\u5eb7\u6210\u4eba\u306b\u304a\u3051\u308b\u6700\u9ad8\u8840\u4e2d\u6fc3\u5ea6\u5230\u9054\u6642\u9593\uff08Tmax\uff09\u306f&#8230;<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-357","post","type-post","status-publish","format-standard","hentry","category-sleep"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/neuro-machida.jp\/blog\/wp-json\/wp\/v2\/posts\/357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neuro-machida.jp\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neuro-machida.jp\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neuro-machida.jp\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/neuro-machida.jp\/blog\/wp-json\/wp\/v2\/comments?post=357"}],"version-history":[{"count":2,"href":"https:\/\/neuro-machida.jp\/blog\/wp-json\/wp\/v2\/posts\/357\/revisions"}],"predecessor-version":[{"id":360,"href":"https:\/\/neuro-machida.jp\/blog\/wp-json\/wp\/v2\/posts\/357\/revisions\/360"}],"wp:attachment":[{"href":"https:\/\/neuro-machida.jp\/blog\/wp-json\/wp\/v2\/media?parent=357"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neuro-machida.jp\/blog\/wp-json\/wp\/v2\/categories?post=357"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neuro-machida.jp\/blog\/wp-json\/wp\/v2\/tags?post=357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}