{"id":307,"date":"2025-07-31T16:26:26","date_gmt":"2025-07-31T07:26:26","guid":{"rendered":"https:\/\/neuro-machida.jp\/blog\/?p=307"},"modified":"2025-08-29T15:19:10","modified_gmt":"2025-08-29T06:19:10","slug":"post-307","status":"publish","type":"post","link":"https:\/\/neuro-machida.jp\/blog\/post-307\/","title":{"rendered":"\u7761\u7720\u85ac\u306e\u7a2e\u985e\u3068\u7279\u5fb4\uff1a\u85ac\u7406\u4f5c\u7528\u304b\u3089\u307f\u305f\u7761\u7720\u85ac"},"content":{"rendered":"\n<p><strong>\u7761\u7720\u85ac\u306f\u98f2\u307e\u306a\u3044\u3067\u3059\u3081\u3070\u305d\u306e\u307b\u3046\u304c\u3088\u3044\u3068\u8a00\u3048\u307e\u3059\u304c\u3001\u7761\u7720\u85ac\u306e\u52a9\u3051\u3092\u501f\u308a\u308c\u3070\u3001\u5feb\u9069\u306b\u904e\u3054\u3059\u3053\u3068\u304c\u3067\u304d\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002\u4f55\u304b\u5fc3\u914d\u306a\u3053\u3068\u3001\u6c17\u306b\u304b\u304b\u308b\u3053\u3068\u304c\u3042\u308b\u3068\u7720\u308c\u306a\u304f\u306a\u308b\u3053\u3068\u306f\u3057\u3070\u3057\u3070\u7d4c\u9a13\u3057\u307e\u3059\u3002\u307e\u305f\u3001\u3044\u308d\u3044\u308d\u306a\u75c5\u6c17\u3067\u4e0d\u7720\u3068\u306a\u308b\u3053\u3068\u3082\u3042\u308a\u3048\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<p><strong>\u307e\u305a\u306f\u3001\u7761\u7720\u74b0\u5883\u3092\u6574\u3048\u307e\u3059\u3002\u904e\u5ea6\u306e\u30a2\u30eb\u30b3\u30fc\u30eb\u6442\u53d6\u3092\u63a7\u3048\u3001\u5bdd\u308b\u524d\u306e\u30b3\u30fc\u30d2\u30fc\u306a\u3069\u306e\u30ab\u30d5\u30a7\u30a4\u30f3\u6442\u53d6\u3092\u63a7\u3048\u307e\u3059\u3002\u898f\u5247\u6b63\u3057\u3044\u751f\u6d3b\u3092\u9001\u308a\u3001\u671d\u306e\u98df\u4e8b\u3092\u6b20\u304b\u3059\u3053\u3068\u306a\u304f\u3001\u65e5\u4e2d\u306b\u904b\u52d5\u3092\u3057\u3066\u65e5\u306b\u5f53\u305f\u308b\u3088\u3046\u306b\u5fc3\u304c\u3051\u3001\u5fc3\u5730\u3088\u3044\u300c\u5bdd\u5e8a\u300d\u3092\u4f5c\u308a\u307e\u3057\u3087\u3046\u3002\u3000<\/strong><\/p>\n\n\n\n<p><strong>\u307e\u305f\u3001\u7761\u7720\u85ac\u306f\u98f2\u307f\u7d9a\u3051\u308b\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u306a\u304f\u3066\u7720\u308c\u308b\u3088\u3046\u306b\u306a\u308b\u3053\u3068\u304c\u6700\u7d42\u76ee\u6a19\u3068\u306a\u308a\u307e\u3059\u3002\u7761\u7720\u85ac\u3092\u7528\u3044\u3066\u7720\u308c\u3066\u3044\u308b\u3068\u304d\u306b\u3053\u305d\u3001\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u3084\u4e0d\u7720\u306e\u539f\u56e0\u3092\u53d6\u308a\u9664\u304f\u3053\u3068\u3092\u5fc3\u304c\u3051\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/strong><\/p>\n\n\n\n<p><strong>\u7761\u7720\u85ac\u3092\u670d\u7528\u3057\u3066\u3044\u3066\u3082\u7720\u308c\u306a\u3044\u3068\u3044\u3046\u60a3\u8005\u3055\u3093\u304c\u304a\u3089\u308c\u307e\u3059\u304c\u3001\u85ac\u3092\u3046\u307e\u304f\u8abf\u6574\u3059\u308b\u3053\u3068\u3067\u7720\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002\u5f53\u9662\u3067\u306f\u4e0b\u8a18\u306b\u793a\u3059\u85ac\u306a\u3069\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u3001\u751f\u6d3b\u7fd2\u6163\u306e\u6539\u5584\u3092\u4fc3\u3057\u3001\u85ac\u306a\u3057\u3067\u7720\u308c\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u307e\u3059\u3002<\/strong><\/p>\n\n\n\n<p><strong>\u8133\u5185\u306e\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306e\u50cd\u304d\u304b\u3089\u7761\u7720\u85ac\u306e\u85ac\u7406\u4f5c\u7528\u3092\u7406\u89e3\u3057\u307e\u3057\u3087\u3046\u3002<\/strong><\/p>\n\n\n\n<p><strong>\uff11\u5e02\u8ca9\u85ac\u3000\u30d2\u30b9\u30bf\u30df\u30f3H<sub>1<\/sub>\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac<\/strong><\/p>\n\n\n\n<p>\u5e02\u8ca9\u306e\u7761\u7720\u85ac\u306e\u4e3b\u6210\u5206\u306f<strong>\u30b8\u30d5\u30a7\u30f3\u30d2\u30c9\u30e9\u30df\u30f3\u5869\u9178\u5869<\/strong>\u3067\u3059\u3002\u4e00\u822c\u306e\u6297\u30a2\u30ec\u30eb\u30ae\u30fc\u85ac\u304c\u7720\u304f\u306a\u308b\u306e\u3082\u540c\u69d8\u306e\u6a5f\u5e8f\u306b\u3088\u308a\u307e\u3059\u3002\u30d2\u30b9\u30bf\u30df\u30f3\u306f\u8133\u5185\u3067\u306f\u899a\u9192\u3092\u8abf\u7bc0\u3057\u3066\u3044\u308b<strong>\u8996\u5e8a\u4e0b\u90e8\u306e\u7d50\u7bc0\u4e73\u982d\u6838(TMN)\u7d30\u80de<\/strong>\u3067\u7523\u751f\u3055\u308c\u3001\u524d\u982d\u524d\u76ae\u8cea\u3001\u524d\u8133\u57fa\u5e95\u90e8\u3001\u8996\u5e8a\u3001\u8133\u5e79\u306a\u3069\u8133\u306e\u5927\u534a\u306b\u6295\u5c04\u3057\u3066\u3044\u307e\u3059\u3002\u899a\u9192\u7cfb\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306e\u306a\u304b\u3067\u3082\u91cd\u8981\u306a\u4f4d\u7f6e\u3092\u5360\u3081\u308b\u30d2\u30b9\u30bf\u30df\u30f3\u306eH<sub>1<\/sub>\u53d7\u5bb9\u4f53\u3092\u906e\u65ad\u3059\u308b\u306e\u306f\u7761\u7720\u85ac\u3068\u3057\u3066\u52b9\u679c\u7684\u3068\u8003\u3048\u3089\u308c\u3066\u304a\u308a\u3001\u5e02\u8ca9\u306e\u7761\u7720\u85ac\u3068\u3057\u3066\u91cd\u5b9d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u8010\u6027\uff08\u6642\u9593\u3068\u3068\u3082\u306b\u85ac\u306e\u52b9\u679c\u304c\u8584\u308c\u308b\uff09\u306f\u304a\u3053\u308a\u307e\u3059\u304c\u3001\u96e2\u8131\u4f5c\u7528\uff08\u85ac\u3092\u3084\u3081\u305f\u6642\u306b\u3067\u308b\u8af8\u75c7\u72b6\uff09\u3001\u4f9d\u5b58\u3001\u53cd\u8df3\u6027\u4e0d\u7720\uff08\u3082\u3068\u3082\u3068\u306e\u4e0d\u7720\u3088\u308a\u60aa\u5316\uff09\u306f\u8d77\u3053\u308a\u307e\u305b\u3093\u3002\u591a\u304f\u306e\u85ac\u5264\u306fH<sub>1<\/sub>\u53d7\u5bb9\u4f53\u306b\u9078\u629e\u7684\u3067\u306f\u306a\u304f\u30e0\u30b9\u30ab\u30ea\u30a4\u30f3\uff2d<sub>\uff11<\/sub>\u53d7\u5bb9\u4f53\u306b\u3082\u62ee\u6297\u3059\u308b\u305f\u3081\u3001\u53e3\u559d\uff08\u553e\u6db2\u5206\u6ccc\u6291\u5236\uff09\u3001\u4fbf\u79d8\uff08\u6d88\u5316\u7ba1\u904b\u52d5\u6291\u5236\uff09\u3001\u6392\u5c3f\u56f0\u96e3\uff08\u8180\u80f1\u5f1b\u7de9\uff09\u3001\u773c\u5727\u4e0a\u6607\u306a\u3069\u306e\u6297\u30b3\u30ea\u30f3\u4f5c\u7528\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\uff12\u4e0d\u7720\u75c7\u85ac\u3068\u3057\u3066\u4fdd\u967a\u53ce\u8f09\u3055\u308c\u3066\u3044\u308b\u85ac<\/strong><\/p>\n\n\n\n<p><strong>\u2460\u3000\u30d9\u30f3\u30be\u30b8\u30a2\u30bc\u30d4\u30f3\u7cfb\u7761\u7720\u85ac\u3000\u30c8\u30ea\u30a2\u30be\u30e9\u30e0\uff08\u30cf\u30eb\u30b7\u30aa\u30f3\uff09\u30fb\u30d6\u30ed\u30c1\u30be\u30e9\u30e0\uff08\u30ec\u30f3\u30c9\u30eb\u30df\u30f3\uff09\u30fb\u30ed\u30eb\u30e1\u30bf\u30bc\u30d1\u30e0\uff08\u30a8\u30d0\u30df\u30fc\u30eb\uff09\u30fb\u30ea\u30eb\u30de\u30b6\u30db\u30f3\uff08\u30ea\u30b9\u30df\u30fc\uff09\u30fb\u30a8\u30c1\u30be\u30e9\u30e0\uff08\u30c7\u30d1\u30b9\uff09\u30fb\u30a8\u30b9\u30bf\u30be\u30e9\u30e0\uff08\u30e6\u30fc\u30ed\u30b8\u30f3\uff09\u30fb\u30cb\u30c8\u30e9\u30bc\u30d1\u30e0\uff08\u30d9\u30f3\u30b6\u30ea\u30f3\uff09\u30fb\u30d5\u30eb\u30cb\u30c8\u30e9\u30bc\u30d1\u30e0\uff08\u30b5\u30a4\u30ec\u30fc\u30b9\uff09\u30fb\u30af\u30a2\u30bc\u30d1\u30e0\uff08\u30c9\u30e9\u30fc\u30eb\uff09\u30fb\u30d5\u30eb\u30e9\u30bc\u30d1\u30e0\uff08\u30c0\u30eb\u30e1\u30fc\u30c8\uff09\u30fb\u30cf\u30ed\u30ad\u30b5\u30be\u30e9\u30e0\uff08\u30bd\u30e1\u30ea\u30f3\uff09\u306a\u3069GABA\uff08\u03b3\u30a2\u30df\u30ce\u916a\u9178\uff09\u4f5c\u52d5\u85ac\uff08GABA<sub>A<\/sub>\u53d7\u5bb9\u4f53\u306e\u6b63\u306e\u30a2\u30ed\u30b9\u30c6\u30ea\u30c3\u30af\u8abf\u7bc0\u7269\u8cea\uff09<\/strong><\/p>\n\n\n\n<p><strong>\u8996\u5e8a\u4e0b\u90e8\u306e\u8179\u5916\u5074\u8996\u7d22\u524d\u91ce(VLPO)<\/strong>\u304b\u3089\u751f\u3058\u308b\u6291\u5236\u7cfb\u7761\u7720\u56de\u8def\u5185\u3067GABA\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u3092\u4fc3\u9032\u3057\u4e0d\u7720\u75c7\u306b\u52b9\u679c\u3092\u793a\u3057\u307e\u3059\u3002GABA\u306e\u4f5c\u52d5\u306f\u3001\u7d50\u7bc0\u4e73\u982d\u6838(TMN\u3000\u30d2\u30b9\u30bf\u30df\u30f3)\u3001\u5916\u5074\u8996\u5e8a\u4e0b\u90e8\uff08\u30aa\u30ec\u30ad\u30b7\u30f3\uff09\u3001\u524d\u8133\u57fa\u5e95\u90e8\uff08\u30a2\u30bb\u30c1\u30eb\u30b3\u30ea\u30f3\uff09\u306a\u3069\u306e\u899a\u9192\u4fc3\u9032\u90e8\u4f4d\u3092\u6291\u5236\u3057\u7761\u7720\u306b\u5c0e\u304f\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<a>GABA<\/a>\u306f\u3001\u8133\u306e\u4e2d\u3067\u795e\u7d4c\u306e\u8208\u596e\u3092\u6291\u3048\u308b\u50cd\u304d\u3092\u3059\u308b\u4e3b\u8981\u306a\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u3067\u3059\u3002GABA \u304cGABA<sub>A<\/sub> \u53d7\u5bb9\u4f53\u3068\u3044\u3046\u5834\u6240\u306b\u304f\u3063\u3064\u304f\u3068\u3001\u795e\u7d4c\u7d30\u80de\u306e\u4e2d\u306b\u5869\u7d20\u30a4\u30aa\u30f3\u304c\u6d41\u308c\u8fbc\u307f\u3001\u795e\u7d4c\u7d30\u80de\u306e\u819c\u306e\u96fb\u4f4d\u304c\u5909\u5316\u3057\u3066\u3001\u795e\u7d4c\u306e\u8208\u596e\u304c\u6291\u3048\u3089\u308c\u307e\u3059\u3002GABA<sub>A<\/sub> \u53d7\u5bb9\u4f53\u306b\u306f\u3001GABA \u304c\u7d50\u5408\u3059\u308b\u90e8\u4f4d\u3068\u306f\u5225\u306b\u3001\u30d9\u30f3\u30be\u30b8\u30a2\u30bc\u30d4\u30f3\u7cfb\u85ac\u304c\u7d50\u5408\u3059\u308b\u90e8\u4f4d\u304c\u3042\u308a\u307e\u3059\uff08\u5225\u306e\u5834\u6240\u3092\u610f\u5473\u3059\u308b\u30a2\u30ed\u30b9\u30c6\u30ea\u30c3\u30af\uff09\u3002\u30d9\u30f3\u30be\u30b8\u30a2\u30bc\u30d4\u30f3\u7cfb\u85ac\u304cGABA<sub>A<\/sub> \u53d7\u5bb9\u4f53\u306e\u30d9\u30f3\u30be\u30b8\u30a2\u30bc\u30d4\u30f3\u7d50\u5408\u90e8\u4f4d\u306b\u7d50\u5408\u3059\u308b\u3068\u3001GABA \u53d7\u5bb9\u4f53\u306e\u5f62\u304c\u5909\u5316\u3057\u3001\u3088\u308a\u52b9\u7387\u7684\u306b\u5869\u7d20\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u304c\u958b\u304d\u307e\u3059\u3002<br><\/p>\n\n\n\n<p><strong>\u2461\u3000Z\u30c9\u30e9\u30c3\u30b0\u3000\u30be\u30eb\u30d4\u30c7\u30e0\uff08\u30de\u30a4\u30b9\u30ea\u30fc\uff09\u30fb\u30a8\u30b9\u30be\u30d4\u30af\u30ed\u30f3\uff08\u30eb\u30cd\u30b9\u30bf\uff09\u30fb\u30be\u30d4\u30af\u30ed\u30f3\uff08\u30a2\u30e2\u30d0\u30f3\uff09GABA\uff08\u03b3\u30a2\u30df\u30ce\u916a\u9178\uff09\u4f5c\u52d5\u85ac\uff08GABA<sub>A<\/sub>\u53d7\u5bb9\u4f53\u306e\u6b63\u306e\u30a2\u30ed\u30b9\u30c6\u30ea\u30c3\u30af\u8abf\u7bc0\u7269\u8cea\uff09<\/strong><\/p>\n\n\n\n<p>\u30d9\u30f3\u30be\u30b8\u30a2\u30bc\u30d4\u30f3\u7cfb\u85ac\u306e\u3088\u3046\u306b\u30d9\u30f3\u30be\u30b8\u30a2\u30bc\u30d4\u30f3\u9aa8\u683c\u306f\u6301\u3061\u307e\u305b\u3093\u304c\u3001\u30d9\u30f3\u30be\u30b8\u30a2\u30bc\u30d4\u30f3\u7cfb\u85ac\u306e\u3088\u3046\u306b\u3001GABA<sub>A<\/sub>\u53d7\u5bb9\u4f53\u306eGABA\u81ea\u8eab\u304c\u7d50\u5408\u3059\u308b\u90e8\u5206\u3068\u306f\u7570\u306a\u308b\u90e8\u4f4d\u306b\u4f5c\u7528\u3057\u307e\u3059\uff08\u30a2\u30ed\u30b9\u30c6\u30ea\u30c3\u30af\uff09\u3002\u30d9\u30f3\u30be\u30b8\u30a2\u30bc\u30d4\u30f3\u7cfb\u85ac\u3068\u306f\u7d50\u5408\u3059\u308b\u90e8\u4f4d\u3084\u305d\u306e\u9078\u629e\u6027\u304c\u7570\u306a\u308b\u305f\u3081\u306b\uff08\u8a73\u7d30\u306f\u4e0d\u660e\uff09\u3001\u6642\u9593\u3068\u3068\u3082\u306b\u52b9\u679c\u304c\u8584\u308c\u308b\u8010\u6027\u3084\u3001\u4e2d\u6b62\u3059\u308b\u3068\u73fe\u308c\u308b\u96e2\u8131\u52b9\u679c\u3001\u3082\u3068\u3082\u3068\u306e\u4e0d\u7720\u3088\u308a\u60aa\u5316\u3059\u308b\u53cd\u8df3\u6027\u4e0d\u7720\u306a\u3069\u3092\u5f15\u304d\u8d77\u3053\u3059\u30ea\u30b9\u30af\u306f\u5c11\u306a\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30a8\u30b9\u30be\u30d4\u30af\u30ed\u30f3\u306f\u6700\u3082\u6709\u7528\u306a\u85ac\u306e\u4e00\u3064\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u2782\u3000\u30e1\u30e9\u30c8\u30cb\u30f3\u7cfb\u7761\u7720\u85ac\u3000\u30e1\u30e9\u30c8\u30cb\u30f3\u3000\u30e9\u30e1\u30eb\u30c6\u30aa\u30f3\uff08\u30ed\u30bc\u30ec\u30e0\uff09\u30e1\u30e9\u30c8\u30cb\u30f3MT<sub>1<\/sub>MT<sub>2<\/sub>\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac<\/strong><\/p>\n\n\n\n<p>\u30d2\u30c8\uff08\u52d5\u7269\uff09\u306b\u306f\u30b5\u30fc\u30ab\u30c7\u30a3\u30a2\u30f3\u30ea\u30ba\u30e0\uff08\u6982\u65e5\u30ea\u30ba\u30e0\u3000\u4f53\u5185\u6642\u8a08\uff09\u304c\u3042\u308a\u3001\u7761\u7720\u3068\u899a\u9192\u306e\u30b5\u30a4\u30af\u30eb\u3001\u4f53\u6e29\u3001\u30db\u30eb\u30e2\u30f3\u3001\u81ea\u5f8b\u795e\u7d4c\u3001\u514d\u75ab\u6a5f\u80fd\u306a\u3069\u3092\u53f8\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u304c\u6574\u3063\u3066\u3044\u308b\u3053\u3068\u3067\u5065\u5eb7\u7684\u306a\u751f\u6d3b\u304c\u7dad\u6301\u3067\u304d\u307e\u3059\u3002\u30b5\u30fc\u30ab\u30c7\u30a4\u30a2\u30f3\u30ea\u30ba\u30e0\u306e\u8abf\u6574\u306b\u306f\u69d8\u3005\u306a\u8981\u56e0\u304c\u5f71\u97ff\u3057\u307e\u3059\u304c\u3001\u5149\u306f\u6700\u3082\u5f37\u529b\u306a\u540c\u671f\u88c5\u7f6e\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u76ee\u304b\u3089\u5149\u304c\u5165\u308b\u3068\u8996\u5e8a\u4e0b\u90e8\u306e\u8996\u4ea4\u53c9\u4e0a\u6838(SCN)\u306b\u30b7\u30b0\u30ca\u30eb\u304c\u9001\u3089\u308c\u3001\u305d\u3053\u304b\u3089\u677e\u679c\u4f53\u306b\u30b7\u30b0\u30ca\u30eb\u304c\u5c4a\u304d\u3001\u30e1\u30e9\u30c8\u30cb\u30f3\u306e\u7523\u751f\u304c\u3068\u307e\u308a\u307e\u3059\u3002\u6697\u95c7\u306b\u306a\u308b\u3068\u540c\u69d8\u306e\u7d4c\u8def\u3092\u7d4c\u3066\u677e\u679c\u4f53\u304b\u3089\u30e1\u30e9\u30c8\u30cb\u30f3\u304c\u7523\u751f\u30fb\u5206\u6ccc\u3055\u308c\u307e\u3059\u3002\u8996\u4ea4\u53c9\u4e0a\u6838\uff08SCN\uff09\u306f\u4f53\u5185\u6642\u8a08\u306e\u4e2d\u67a2\u3067\u3042\u308a\u3001\u30e1\u30e9\u30c8\u30cb\u30f3\u306f\u3053\u3053\u306e\u30e1\u30e9\u30c8\u30cb\u30f3MT<sub>1<\/sub> MT<sub>2<\/sub>\u53d7\u5bb9\u4f53\u306b\u4f5c\u7528\u3057\u3066\u7761\u7720\u3092\u5c0e\u304d\u307e\u3059\u3002\u30e9\u30e1\u30eb\u30c6\u30aa\u30f3\u306f\u30e1\u30e9\u30c8\u30cb\u30f3MT<sub>1<\/sub> MT<sub>2<\/sub>\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3067\u3001\u81ea\u7136\u306a\u7761\u7720\u3092\u4fc3\u3059\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7761\u7720\u85ac\u3068\u3057\u3066\u306e\u4f5c\u7528\u306f\u3084\u3084\u5f31\u3081\u3067\u3059\u3002<\/p>\n\n\n\n<p><strong>\u2463\u3000\u30aa\u30ec\u30ad\u30b7\u30f3\u7cfb\u7761\u7720\u85ac\u3000\u30ec\u30f3\u30dc\u30ad\u30b5\u30f3\u30c8\uff08\u30c7\u30a8\u30d3\u30b4\uff09\u30b9\u30dc\u30ec\u30ad\u30b5\u30f3\u30c8\uff08\u30d9\u30eb\u30bd\u30e0\u30e9\uff09\u30c0\u30ea\u30c9\u30ec\u30ad\u30b5\u30f3\u30c8\uff08\u30af\u30fc\u30d3\u30d3\u30c3\u30af\uff09\u4e8c\u91cd\u30aa\u30ec\u30ad\u30b7\u30f3\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac(DORA)<\/strong><\/p>\n\n\n\n<p>\u30aa\u30ec\u30ad\u30b7\u30f3\uff08\u30d2\u30dd\u30af\u30ec\u30c1\u30f3\uff09\u306f\u5916\u5074\u8996\u5e8a\u4e0b\u90e8\u30fb\u8996\u5e8a\u4e0b\u90e8\u5f8c\u90e8\u3067\u7523\u751f\u3055\u308c\u3001\u30aa\u30ec\u30ad\u30b7\u30f3\u795e\u7d4c\u7d30\u80de\u306f\u7d50\u7bc0\u4e73\u982d\u6838(TMN)\u3001\u524d\u8133\u57fa\u5e95\u90e8\u3001\u8996\u5e8a\u3001\u305d\u3057\u3066\u8133\u5e79\u3092\u542b\u3080\u8133\u306e\u3055\u307e\u3056\u307e\u306a\u90e8\u4f4d\u306b\u6295\u5c04\u3057\u3066\u3044\u307e\u3059\u3002\u30aa\u30ec\u30ad\u30b7\u30f3\u305d\u306e\u3082\u306e\u306f\u899a\u9192\u3092\u5f15\u304d\u8d77\u3053\u3059\u899a\u9192\u7cfb\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u3068\u306f\u8a00\u3048\u307e\u305b\u3093\u304c\u3001\u30a2\u30bb\u30c1\u30eb\u30b3\u30ea\u30f3\u3001\u30ce\u30eb\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u3001\u30d2\u30b9\u30bf\u30df\u30f3\u3001\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u3001\u30c9\u30d1\u30df\u30f3\u306a\u3069\u306e\u5168\u899a\u9192\u7cfb\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u308a\u899a\u9192\u72b6\u614b\u306e\u5b89\u5b9a\u5316\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4e8c\u91cd\u30aa\u30ec\u30ad\u30b7\u30f3\u53d7\u5bb9\u4f53\u30a2\u30f3\u30bf\u30b4\u30cb\u30b9\u30c8\uff08DORA\uff09\u306f\u3001\uff12\u3064\u3042\u308b\u30aa\u30ec\u30ad\u30b7\u30f3\u53d7\u5bb9\u4f53OX<sub>1<\/sub>OX<sub>2<\/sub>\u3092\u53cc\u65b9\u3068\u3082\u306b\u906e\u65ad\u3059\u308b\u305f\u3081\u3053\u3046\u547c\u3070\u308c\u307e\u3059\u3002\u5165\u7720\u3060\u3051\u3067\u306a\u304f\u7761\u7720\u306e\u7dad\u6301\u3092\u6539\u5584\u3057\u3001\u4f9d\u5b58\u3001\u96e2\u8131\u4f5c\u7528\u3001\u53cd\u8df3\u6027\u4e0d\u7720\u3001\u3075\u3089\u3064\u304d\u3001\u6df7\u4e71\u3001\u5065\u5fd8\u3084\u547c\u5438\u6291\u5236\u306f\u304a\u304d\u307e\u305b\u3093\u3002\u30aa\u30ec\u30ad\u30b7\u30f3\u306e\u8840\u4e2d\u6fc3\u5ea6\u306f\u671d\u9ad8\u304f\u306a\u308b\u305f\u3081\u3001DORA\u306e\u5bfe\u30aa\u30ec\u30ad\u30b7\u30f3\u6bd4\u304c\u4f4e\u304f\u306a\u308a\u899a\u9192\u3059\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u30aa\u30ec\u30ad\u30b7\u30f3\u7cfb\u7761\u7720\u85ac\u306fREM\u7761\u7720\u3092\u5897\u3084\u3059\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5922\u3092\u898b\u304c\u3061\u306b\u306a\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002DORA\u306f\u3044\u305a\u308c\u3082\u809d\u81d3\u306eCYP3A\u3067\u5206\u89e3\u3055\u308c\u308b\u305f\u3081\u3001\u30af\u30e9\u30ea\u30b9\u30ed\u30de\u30a4\u30b7\u30f3\u306a\u3069CYP3A\u3092\u963b\u5bb3\u3059\u308b\u85ac\u3068\u4f75\u7528\u3059\u308b\u3068\u8840\u4e2d\u6fc3\u5ea6\u304c\u4e0a\u304c\u308a\u4f5c\u7528\u304c\u5f37\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\uff13\u4e0d\u7720\u75c7\u4ee5\u5916\u306e\u75c5\u6c17\u3067\u7528\u3044\u3089\u308c\u7761\u7720\u85ac\u3068\u3057\u3066\u4f7f\u7528\u3059\u308b\u3053\u3068\u3082\u3042\u308b\u85ac\uff08\u4e0d\u7720\u75c7\u85ac\u3068\u3057\u3066\u306f\u4fdd\u967a\u53ce\u8f09\u3055\u308c\u3066\u3044\u306a\u3044\uff09<\/strong><\/p>\n\n\n\n<p>\u6297\u3046\u3064\u5264\u3067\u7720\u6c17\u306e\u5f37\u3044\u85ac\u306f\u93ae\u9759\u7cfb\u6297\u3046\u3064\u85ac\u3068\u547c\u3070\u308c\u3066\u3044\u307e\u3059\u3002\u4e0b\u8a18\u306e\u85ac\u5264\u306f\u7761\u7720\u85ac\u3068\u3057\u3066\u7528\u3044\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p><strong>\u2460\u3000\u30af\u30a8\u30c1\u30a2\u30d4\u30f3\u3000\u30bb\u30ed\u30c8\u30cb\u30f35HT2<sub>A<\/sub>\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\u30c9\u30d1\u30df\u30f3D<sub>2<\/sub>\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac<\/strong><\/p>\n\n\n\n<p>\u30af\u30a8\u30c1\u30a2\u30d4\u30f3\u305d\u306e\u3082\u306e\u306f5HT<sub>2A<\/sub>\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\u3001D<sub>2<\/sub>\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\u3067\u3059\u304c\u3001\u305d\u306e\u4ee3\u8b1d\u7269\u306b\u3082\u85ac\u7406\u6d3b\u6027\u304c\u3042\u308b\u305f\u3081\u306b\u591a\u5f69\u306a\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306e\u53d7\u5bb9\u4f53\uff08\u30bb\u30ed\u30c8\u30cb\u30f35HT<sub>7<\/sub> 5HT<sub>2C<\/sub>\u53d7\u5bb9\u4f53\u62ee\u6297<sub>\u3000<\/sub>\u30ce\u30eb\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u03b1<sub>2<\/sub>\u53d7\u5bb9\u4f53\u62ee\u6297\u3000\u30bb\u30ed\u30c8\u30cb\u30f35HT<sub>1A<\/sub>\u90e8\u5206\u53d7\u5bb9\u4f53\u62ee\u6297 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SNRI\u3068\u306f\u4f5c\u7528\u304c\u7570\u306a\u308a\u307e\u3059\uff09\u3001\uff15\u3064\u306e\u4e3b\u8981\u306a\u4f5c\u7528\u6a5f\u5e8f\u304c\u3042\u308a\u307e\u3059\uff08\u30bb\u30ed\u30c8\u30cb\u30f35HT<sub>2A<\/sub> 5HT<sub>2C<\/sub> 5HT<sub>3<\/sub>\u53d7\u5bb9\u4f53\u62ee\u6297 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0a8\u30f3\u30b9\u30fb\u30a4\u30f3\u30bf\u30fc\u30ca\u30b7\u30e7\u30ca\u30eb<\/p>\n\n\n\n<p>De Crescenzo F, D&#8217;Al\u00f2 GL, Ostinelli EG, Ciabattini M, Di Franco V, Watanabe N, Kurtulmus A, Tomlinson A, Mitrova Z, Foti F, Del Giovane C, Quested DJ, Cowen PJ, Barbui C, Amato L, Efthimiou O, Cipriani A. Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis. Lancet. 2022 Jul 16;400(10347):170-184. doi: 10.1016\/S0140-6736(22)00878-9. 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