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1954\u5e74\u3001Edward D. Freis\u306f\u4ea4\u611f\u795e\u7d4c\u6291\u5236\u4f5c\u7528\u306e\u3042\u308b\u30ad\u30e7\u30a6\u30c1\u30af\u30c8\u30a6\u79d1\u306e\u30a4\u30f3\u30c9\u30b8\u30e3\u30dc\u30af\u304b\u3089\u7cbe\u88fd\u3055\u308c\u305f\u30ec\u30bb\u30eb\u30d4\u30f3reserpine\u30925\u4eba\u306e\u9ad8\u8840\u5727\u60a3\u8005\u306b\u6295\u4e0e\u3057\u3001\u6ce8\u610f\u6df1\u304f\u89b3\u5bdf\u3057\u307e\u3057\u305f\u3002\u3059\u308b\u3068\u5168\u54e1\u306b\u7761\u7720\u969c\u5bb3\u3084\u7121\u5feb\u611f\u75c7anhedonia\u306a\u3069\u306e\u3046\u3064\u69d8\u306e\u75c7\u72b6\u304c\u73fe\u308c\u3001\u9577\u671f\u6295\u4e0e\u3067\u81ea\u6bba\u9858\u671b\u307e\u3067\u73fe\u308c\u305f\u306e\u3067\u3057\u305f\u3002\u85ac\u3092\u3084\u3081\u308b\u3068\u75c7\u72b6\u306f\u6d88\u5931\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u5f8c\u540c\u69d8\u306e\u5831\u544a\u304c\u76f8\u6b21\u304e\u307e\u3057\u305f\u3002\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u30661950\u5e74\u4ee3\u306b\u3001\u30a4\u30cc\u306b\u30ec\u30bb\u30eb\u30d4\u30f3\u3092\u6295\u4e0e\u3059\u308b\u3068\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u4ee3\u8b1d\u7523\u7269\u3067\u3042\u308b5- HTIAA\u304c\u5927\u91cf\u306b\u6392\u51fa\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\uff12\u56de\u6295\u4e0e\u3057\u3066\u3082\u3053\u306e\u53cd\u5fdc\u306f\u898b\u3089\u308c\u306a\u3044\u3053\u3068\u304b\u3089\u3001\u6700\u521d\u306e\u53cd\u5fdc\u306f\u3001\u84c4\u3048\u3089\u308c\u3066\u3044\u305f\u30bb\u30ed\u30c8\u30cb\u30f3\u304c\u653e\u51fa\u3055\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u30ec\u30bb\u30eb\u30d4\u30f3\u3092\u6295\u4e0e\u3055\u308c\u305f\u30a4\u30cc\u306e\u8996\u5e8a\u4e0b\u90e8\u3068\u5c3e\u72b6\u6838\u3067\u30bb\u30ed\u30c8\u30cb\u30f3\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u305d\u306e\u5f8c\u3057\u3070\u3089\u304f\u3057\u3066\u3001\u30ec\u30bb\u30eb\u30d4\u30f3\u306e\u4f5c\u7528\u306f\u3001vesicular monoamine transporter- 2 (VMAT- 2)\u306e\u963b\u5bb3\u306b\u3088\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u4e00\u65b9\u30011952\u5e74\u3001Selikoff \u3089\u306f\u3001\u30cb\u30e5\u30fc\u30e8\u30fc\u30af\u306e\u30b9\u30bf\u30c6\u30f3\u5cf6Staten Island \u306e\u7d50\u6838\u7642\u990a\u6240\uff08Seaview Hospital\uff09\u3067\u3001\u6297\u7d50\u6838\u85ac\u3068\u3057\u3066\u52d5\u7269\u5b9f\u9a13\u304b\u30892\u5e74\u3067\u30d2\u30c8\u306b\u7528\u3044\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u30a4\u30d7\u30ed\u30cb\u30a2\u30b8\u30c9iproniazid\u304c\u7d50\u6838\u60a3\u8005\u306b\u9a5a\u304f\u3079\u304d\u5909\u5316\u3092\u3082\u305f\u3089\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u5e78\u798f\u611f\u304c\u5897\u3057\u3001\u6d3b\u529b\u3084\u98df\u6b32\u304c\u5897\u52a0\u3057\u3001\u7642\u990a\u6240\u3092\u51fa\u305f\u3044\u3068\u3044\u3046\u8005\u3082\u3042\u3089\u308f\u308c\u307e\u3057\u305f\u3002\u54b3\u304c\u805e\u3053\u3048\u308b\u3060\u3051\u306e\u6697\u3044\u96f0\u56f2\u6c17\u306e\u7642\u990a\u6240\u304c\u660e\u308b\u304f\u306a\u3063\u305f\u3068\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30de\u30a6\u30b9\u306b\u30ec\u30bb\u30eb\u30d4\u30f3\u3092\u6295\u4e0e\u3059\u308b\u3068\u30de\u30a6\u30b9\u306e\u52d5\u304d\u304c\u920d\u304f\u306a\u308a\u307e\u3059\u304c\u3001\u30a4\u30d7\u30ed\u30cb\u30a2\u30b8\u30c9\u304c\u6539\u5584\u3059\u308b\u3068\u3044\u3046\u5831\u544a\u304c\u3055\u308c\u307e\u3057\u305f\u3002Kline\u3089\u306f\u3053\u308c\u306b\u6ce8\u76ee\u3057\u3001\u3046\u3064\u75c5\u306e\u60a3\u8005\u3055\u3093\u306b\u30a4\u30d7\u30ed\u30cb\u30a2\u30b8\u30c9\u3092\u6295\u4e0e\u3059\u308b\u306870%\u306e\u60a3\u8005\u3055\u3093\u306b\u52b9\u679c\u304c\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u57fa\u790e\u7814\u7a76\u306e\u5206\u91ce\u3067\u306f\u30011952\u5e74\u3001Zeller\u3089\u304c\u3001\u30a4\u30d7\u30ed\u30cb\u30a2\u30b8\u30c9\u304c\u30bb\u30ed\u30c8\u30cb\u30f3\u306a\u3069\u306e\u30e2\u30ce\u30a2\u30df\u30f3\u3092\u5206\u89e3\u3059\u308b\u9175\u7d20monoamine oxidase (MAO)\u3092\u963b\u5bb3\u3059\u308b\u3068\u3044\u3046\u5831\u544a\u3092\u3057\u3066\u3044\u307e\u3059\u3002\u52d5\u7269\u5b9f\u9a13\u3067\u3082\u3001MOA\u963b\u5bb3\u85ac\u304c\u8133\u5185\u306e\u30bb\u30ed\u30c8\u30cb\u30f3\u6fc3\u5ea6\u3092\u4e0a\u6607\u3055\u305b\u308b\u3053\u3068\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u524d\u99c6\u4f53\u3067\u3042\u308b5-hydroxytrytophan\u3092\u4f7f\u7528\u3059\u308b\u3068\u540c\u69d8\u306e\u4f5c\u7528\u3092\u793a\u3059\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u30a4\u30d7\u30ed\u30cb\u30a2\u30b8\u30c9\u306f\u591a\u304f\u306e\u3046\u3064\u75c5\u60a3\u8005\u306b\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u9ec4\u75b8\u3068\u814e\u6a5f\u80fd\u969c\u5bb3\u306e\u305f\u3081\u4f7f\u7528\u4e2d\u6b62\u3068\u306a\u308a\u3001\u3055\u3089\u306b\u5f37\u529b\u306aMAO\u963b\u5bb3\u5264\u306b\u53d6\u3063\u3066\u4ee3\u308f\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u4ee5\u4e0a\u30011950\u5e74\u4ee3\u306b\u4f7f\u7528\u3055\u308c\u305f\uff12\u3064\u306e\u85ac\u5264\u306e\u76f8\u53cd\u3059\u308b\u526f\u4f5c\u7528\u304c\u767a\u7aef\u3068\u306a\u3063\u3066\u3001\u4eca\u65e5\u591a\u304f\u7528\u3044\u3089\u308c\u3066\u3044\u308bSSRI\u30fbSNRI\u306e\u958b\u767a\u306b\u81f3\u3063\u305f\u3053\u3068\u3092\u8a18\u3057\u307e\u3057\u305f\u3002\u8840\u5727\u3084\u7d50\u6838\u306e\u75c7\u72b6\u306e\u307f\u3092\u89b3\u5bdf\u3057\u3066\u3044\u3066\u306f\u3053\u3046\u306f\u306a\u3089\u306a\u304b\u3063\u305f\u3068\u601d\u3044\u307e\u3059\u3002\u79d1\u5b66\u8005\u306e\u3059\u308b\u3069\u3044\u89b3\u5bdf\u773c\uff08\u30bb\u30ec\u30f3\u30c7\u30a3\u30d4\u30c6\u30a3serendipity\uff09\u304c\u3042\u3063\u305f\u306e\u3060\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u53c2\u8003\u3000<\/p>\n\n\n\n

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L\u00f3pez-Mu\u00f1oz F, Alamo C. Monoaminergic neurotransmission: the history of the discovery of antidepressants from 1950s until today. Curr Pharm Des. 2009;15(14):1563-86.<\/p>\n\n\n\n

Bremshey S, Gro\u00df J, Renken K, Masseck OA. The role of serotonin in depression-A historical roundup and future directions. J Neurochem. 2024 Mar 13.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

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